Helen McCarthy Tyalmuty was born at Tennant Creek in 1972. She spent most of her childhood at Nauiyu Nambiyu Community (Daly River). In 2006, Tyalmuty had her first solo exhibition in Sydney and further solo and group exhibitions quickly followed in Melbourne and Singapore. In August 2007, Tyalmuty was honoured to receive the People's Choice Award at the 24th Telstra National Aboriginal & Torres Strait Islander Art Award for her painting Tyemeny Liman's Wutinggi. Tyalmuty was also a finalist at the 2008 Telstra Awards.
In 2011, Tyalmuty was commissioned to paint the artwork used as the stage backdrop for the Oprah Winfrey show that was filmed in Australia.